Preheat oven to 325°F. Spray a 9×5-inch loaf pan with cooking spray.: When the oven warms to 325°F you will notice a dry, warm aroma and the oven light softens the kitchen air. Preheating ensures the batter begins rising immediately and avoids a dense center. A common mistake is putting the batter into an oven that is not fully up to temperature which can lead to uneven rise, so wait until the dial or digital readout confirms the temp. Lightly spraying the 9×5-inch loaf pan and lining it with a bit of parchment will help the exterior bake properly while the inside cooks through. Watch for the scent of warm metal and faint sweet steam as the pan heats slightly, that tells you things are ready.
Toss the blueberries in a bowl with 2 tablespoons of the flour.: After coating the blueberry with the small amount of flour , you'll notice the berries look dusted and slightly matte rather than glossy, which helps them stay suspended in the batter. This step prevents sinking and uneven pockets of moisture that can create a wet spot in the loaf. A common slip is skipping this toss, which often leads to the blueberry sinking to the bottom and making the loaf unevenly colored. The tactile feel here is soft, with the berry skins giving a faint pop as you stir gently.
Combine remaining flours, baking powder, baking soda, cinnamon and salt in a large bowl. Whisk well.: As you whisk the dry mix, the aroma of cinnamon brightens and the mixture becomes uniform, showing no streaks of whole wheat or clumps of leavening. Sifting or vigorous whisking aerates the flour which creates a lighter crumb and helps the baking powder and baking soda distribute evenly, ensuring consistent rise. Without thorough mixing, pockets of leavening can cause odd doming or bitter spots, so mix until the color is cohesive and the texture is slightly billowy when lifted.
In a medium bowl, mix egg, sugar, vanilla, melted butter, apple sauce and zucchini.: When you combine these wet ingredients, you should sense a gentle sweetness and warm vanilla scent from the vanilla and sugar . The melted butter will add a glossy sheen, and the grated zucchini will lend a faint vegetal note and visible flecks throughout the mix. Be sure the egg is well beaten so it emulsifies; otherwise the batter can separate. Overbeating here is not a concern but under mixing leads to uneven pockets of flavor. The texture should be cohesive and slightly loose, neither watery nor overly thick.
Add to the flour mixture and stir until just blended. Fold in the blueberries.: Once you fold the wet ingredients into the dry, stop mixing as soon as the streaks of flour disappear, you should still see a slightly lumpy batter which prevents gluten overdevelopment and keeps the loaf tender. The batter will be thick but spoonable, and you will catch the scent of cinnamon and warm apple sauce rising as you stir. Gently fold in the blueberry , being careful not to burst them; a few popped berries are fine and add ribbons of color. Overmixing flattens the loaf, so avoid vigorous stirring which can create a tough texture.
Pour batter into the prepared 9×5-inch loaf pan.: As you transfer the batter, it should flow in a slow, ribbon like stream and settle into the pan with a slightly domed top. Smooth the surface with a spatula for even browning, and tap the pan lightly on the counter to release large air bubbles. If the batter is too stiff to spread, it may need a gentle scrape from the bowl sides. A common misstep is overfilling pans, so ensure the batter fills the 9×5-inch loaf pan about two thirds of the way for proper rise and to avoid overflow.
Bake 45-55 minutes, or until a toothpick inserted in the center comes out clean.: During the bake you will smell the cinnamon and sweet apple sauce lifting, and the loaf surface will turn a warm golden brown. Around 45 minutes check for doneness by inserting a toothpick in the center; it should come out clean or with a few moist crumbs but not raw batter. If the toothpick shows wet batter, bake in additional 5 minute increments. Avoid opening the oven too often, as that drops heat and can cause the center to sink. The top should be springy when gently pressed, and you might notice soft bubbling from any berries near the surface.
Cool for about 10 minutes. Remove loaf from pan and let it cool before slicing.: As the loaf cools, it firms up and finishes setting. Ten minutes in the pan allows residual heat to continue cooking the interior gently, while removing it prevents soggy steam from softening the crust. Transfer to a wire rack to cool fully; warm slices can crumble and be difficult to cut cleanly. A hopeful mistake is slicing too early, which yields a gummy texture, so patience yields neat slices with a tender crumb and visible pockets of blueberry .